Sweet Woodruff

Description

Medicinal Parts

The medicinal parts are the dried or fresh aerial parts collected during or shortly before the flowering season.

Flower and Fruit

The flowers are in loose terminal cymes. The petals are fused to a white, funnel-shaped, 1.5-mm tube. The border of the tube is divided in 4 and is 2 to 3.5 mm long. The 4 stamens are fused with the corolla. The involucre bracts are small, lanceolate, or almost bristlelike. The 2-seeded indehiscent fruit is globular, 2 to 3 mm long, and thickly covered with white barbed bristles.

Leaves, Stem, and Root

Sweet Woodruff is a 10 to 35 cm herbaceous perennial with a thin cylindrical circular rhizome. The stem is erect, quadrangular, and smooth. Apart from the bristly nodes, the stem is glabrous and glossy. The leaves are in false whorls of 6 to 9, the lower ones are obovate-oblong, the middle and upper ones are lanceolate to oblong-lanceolate. They are entire-margined, thorny tipped, glabrous, and rough-edged.

Characteristics

Sweet Woodruff is aromatic when dried; the taste is bitter and tangy.

Habitat

The plant grows in northern and central Europe, Siberia, and northern Africa.

Production

Sweet Woodruff herb is the fresh or dried aerial part of Galium odoratum. It is gathered during or shortly before flowering. The herb must be turned regularly while being dried.

Not to be Confused With

Gallium mollugo or Gallium sylvaticum

Other Names

Master of the Wood, Woodwrad, Woodruff

Actions & Pharmacology

Compounds: In the Fresh Plant

O-hydroxycinnamic acid glucoside: melilotoside

Compounds: In the Dried Plant

Coumarin (0.4-1%)

Iridoids: asperuloside (0.05-0.3%), monotropein (0.04%), scandoside

Effects

The coumarin content may impart antiphlogistic, antiedematic, spasmolytic, and lymphokinetic properties. However, due to the low level of coumarin, the therapeutic effect is doubtful.

Indications & Usage

Unproven Uses

Sweet Woodruff is used as a treatment for nervous agitation, sleeplessness, nervous menstrual disorders, congested liver, jaundice, hemorrhoids, circulation disorders, and venous conditions.

Precautions & Adverse Reactions

The freshly harvested plant contains melilotoside as a glycosidic precursor of coumarin. In the process of dehydration, coumarin is released (content up to 1% coumarin in freshly dried drug). Health risks or side effects following the proper administration of designated therapeutic dosages are not recorded. Headache and stupor can occur with the administration of higher dosages of the drug. Susceptible patients could experience liver damage following long-term administration. This effect is reversible following discontinuation of the drug. Liver enzyme values should be monitored.

Dosage

Mode of Administration

The herb is obsolete as a drug in many countries.

Preparation

To make a tea, place 2 teaspoonfuls (1.8 g drug) in one glass water. An infusion of 5% drug is used for insomnia, and a forehead poultice made of crushed herb is used for headache.

Daily Dosage

The average single dose is 1.0 g drug. The preparations can be taken during the day or shortly before going to bed.

Storage

The drug should be protected from light sources to avoid brown coloring.

Literature

Berkowitz WF et al., J Org Chem 47:824. 1982Casley-Smith JR, Casley-Smith JR, Effects of varying doses of 7-hydroxy-coumarin and coumarin in acute lymphoedema and other high-protein oedemas. In: Progress in Lymphology, X, Adelaide, 194-196. 1985.Cox D, O'Kennedy R, Thornes RD, The rarity of liver toxicity in patients treated with coumarine (1,2-Benzopyrone). In: Human Toxikol 8:501-506. 1989.Egan D, O'Kennedy R, Moran E, Cox D, Prosser E, Thornes RD, The pharmacology, metabolism, analysis, and applications of coumarin and coumarin-related compounds. In: Drug Metabolism Reviews 22(5):503-529. 1990.Fentem JH, Fry JR, Thomas NW, Species differences in the hepatotoxicity of coumarin - a comparision of rat and Mongolian gerbil. In: Toxicology 71(1-2):129. 1992.Hardt TJ, Ritschel WA, The effect of coumarin and 7-hydroxycoumarin on in vitro macrophage phagocytosis of latex particles. In: Methods Find Exp Clin Pharmacol 5(1):39-43. 1983.Hausen BM, Schmieder M, The sensitizing capacity of coumarins. In: Contact Dermatitis 15(3):157-163. 1986.Hazleton LW, Tusing TW, Zeitlin BR, Thiesen R, Murer HK, Toxicity of coumarin. In: J Pharmacol Exp Ther 116:348-358. 1956.Rosskopf F, Kraus J, Franz G, Immunological and antitumor effects of coumarin and some derivatives. In: PA 47(2):139-142. 1992.Wüstenberg, P, Baumann G, Verdacht der Toxizität von Cumarin nicht bestätigt. In: PZ 139(13):1058. 1994.

This information is an educational aid only. It is not intended as medical advice for individual conditions or treatments.
Talk to your doctor, nurse, or pharmacist before following any medical regimen to see if it is safe and effective for you. Please read this important disclaimer about the information within our guide.

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